wine

Can someone help me with wine, i need to get it to work

Warning: the specified Windows directory L"C:\\Windows" is not accessible.
Warning: the specified System directory L"C:\\Windows\\System" is not accessible.

What is wrong?

Do you have a /root/.wine/config ?
If yes what's the contents of it.
Have you specified where is the folder containing windows fake C:
And if you did you have to create manually:
C:\windows
C:\windows\system
otherwise you'll have troubles....

Good luck