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The Wine FAQ says
In general, most Windows installations contain vast quantities of garbage that can confuse Wine and make it less reliable. If you can, it's best to install the programs you want into Wine's fake windows drive.
But the clear intent of the Wine developers is that you use Wine without any real Windows DLLs. And it get's better with every release. But if there is a specific DLL you need, you can just copy it to some directory on your Wine PATH.