I've installed the newest version of wine via yum.
If I try to run winecfg from the command line I get:
wine: creating configuration directory '/home/tnunamak/.wine'...
Then it hangs.
Same thing happens if I'm trying to run an app or the filesystem browser. In case it's relevant, I'm running the 64 bit version of Fedora 6, and wine was working great a few days ago on another installation on the same computer.