Nothing -- but your computer seems to have a problem...
If installing or running Wine causes your system to lock up,
you have a system problem. It is extremely unlikely that it's
Wine's fault. In normal operation, Wine is unable to lock up
your computer because of Linux's normal process protection
and time sharing. It's much more likely that you have either
bad video drivers or some other problem that is causing your
system to be unstable.
A few obvious questions:
does glxgears work?
does switching to open source x.org drivers help?
are you overclocking?